منابع مشابه
A minus end checkpoint
A minus end checkpoint B oth ends of microtubules get in on spindle checkpoint signaling. From kinetochores, proteins at microtubule plus ends relay the results of proper spindle-tochromosome attachments. Now, Hannah Müller, Bodo Lange (Max Planck Institute for Molecular Genetics, Berlin, Germany), and colleagues fi nd that, at minus ends, γ-tubulin signals that all is well with microtubule nuc...
متن کاملThe minus end in sight
Microtubules are intrinsically polar structures. A consequence of this polarity is that the two ends of the microtubule polymer exhibit different properties. The more dynamic plus ends and the mechanisms that regulate their behavior have been the focus of much recent attention. Here, we concentrate on the dynamics and regulation of minus ends, which play distinct but equally critical roles in m...
متن کاملMicrotubule Minus-End-Targeting Proteins
Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally and functionally distinct ends, the plus end and the minus end. Over the last decade, numerous studies have shown that microtubule plus-end dynamics play an important role in many vital cellular processes and are controlled by numerous factors, such as microtubule plus-end-tracking proteins (+TIPs). ...
متن کاملgamma-tubulin is a minus end-specific microtubule binding protein
The role of microtubules in mediating chromosome segregation during mitosis is well-recognized. In addition, interphase cells depend upon a radial and uniform orientation of microtubules, which are intrinsically asymmetric polymers, for the directional transport of many cytoplasmic components and for the maintenance of the structural integrity of certain organelles. The slow growing minus ends ...
متن کاملA minus-end motor sees the plus side
ell polarity in fly wing cells is set with extraordinary precision. Out of the distal end of each cell grows an actin-rich protrusion known as a wing hair. Although the wing contains over 30,000 epidermal cells, it produces this distal-specific hair pattern without error. C Wing hairs are locally aligned but lose distal orientation when the global Ft signal is disturbed. and colleagues indicate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1754rr2